Newswire (Published: Wednesday, October 16, 2019, Received: Wednesday, October 16, 2019, 3:30:56 PM CDT)
Word Count: 425
2019 OCT 16 (NewsRx) -- By a
Semen could be considered a liquid biopsy of the organs of male reproductive system and specifically of prostate gland: approximately 40% of semen is derived from prostatic tissue, so that its contents are most likely to contain prostate disease-specific derived molecules. Dr. Larriba’s research group, which focuses on the “Molecular Genetics of Male Infertility and Urogenital Cancer” research line, has determined that the quantification of certain molecules of ribonucleic acid, known as miRNAs, contained in extracellular vesicles from seminal plasma might be clinically useful as non-invasive biomarkers for prostate cancer.
“Our study shows semen exosome miRNA-based models as molecular biomarkers with the potential to improve prostate cancer diagnosis/prognosis efficiency. These miRNA-based tests should provide reliable information that will help physicians to take clinical decisions as well as will save unnecessary invasive biopsies to the patients, improving the efficiency of detection of prostate cancer and patient outcome”,
Prostate cancer is the most prevalent type of malignant male cancer in Western countries. A significant decrease in deaths due to prostate cancer has been associated with the use of the PSA screening test. However, the deficiencies of serum PSA as a biomarker are well documented: “In many cases, having elevated PSA levels does not mean having prostate cancer. Thus, PSA screening has resulted in an over-diagnosis of prostate cancer, and in many unnecessary biopsies of benign disease”
“Our aim is to offer our results to the clinics as a diagnostic test. In that respect, as our next step, we should carry out further prospective studies on larger cohorts of patients before this miRNA-based biomarker could be adopted in the daily clinical practice”, Larriba concludes.
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