Newswire (Published: Thursday, August 8, 2019, Received: Thursday, August 8, 2019, 5:22:40 PM CDT)

Word Count: 476

2019 AUG 08 (NewsRx) -- By a News Reporter-Staff News Editor at Japan Daily Report -- Investigators publish new report on Oncology - Prostate Cancer. According to news reporting out of Gunma, Japan, by NewsRx editors, research stated, “The reoccurrence of androgen-dependent prostate cancer after anti-androgen therapy mainly depends on prostate cancer stem-like cells. To reduce the risk, it is important to delete the cancer stem-like cells.”

Financial support for this research came from (Inoue Enryo Memorial Foundation of Toyo University).

Our news journalists obtained a quote from the research from Toyo University, “Furthermore, to induce differentiation of cancer stem-like cells is critical to abrogate stemness of the cells. Therefore, we tried to investigate a possibility on the establishment of a new effective therapy to eradicate the cancer stem-like cells via the induction of differentiation in this study. Prostate cancer stem-like cells from an androgen-dependent prostate cancer cell line (LNCaP cell) had severe resistance against an anti-androgen therapeutic agent. We selected Bowman-Birk inhibitor (BBI) from soybeans reported as a chemopreventive agent in prostate cancer to differentiate the caner stem-like cells and a-tocopheryl succinate (TOS) known as a mitocan to induce effectively cytotoxic effect against the cancer stem-like cells. In fact, only TOS treatment had cytotoxic effect against the cancer stem-like cells, but the addition of BBI treatment to the cells treated with TOS reinforced TOS-mediated cytotoxicity in the cancer stem-like cells. This reinforcement coincided with the combination-enhanced apoptosis in the stem-like cells. Also, we confirmed caspase9-caspase3 cascade mainly contributed to the enhancement of the cytotoxicity in the stem-like cells caused by the combination, indicating that the reinforcement of BBI on TOS-mediated apoptosis via mitochondria related to the enhancing cytotoxic effect of the combination on the prostate cancer stem-like cells.”

According to the news editors, the research concluded: “Overall, it seems that the combination is an effective new approach to reduce the reoccurrence of prostate cancer targeting prostate cancer stem cells.”

For more information on this research see: Combination Effect of Bowman-birk Inhibitor and Alpha-tocopheryl Succinate On Prostate Cancer Stem-like Cells. Journal of Nutritional Science and Vitaminology, 2019;65(3):272-277. Journal of Nutritional Science and Vitaminology can be contacted at: Center Academic Publ Japan, 2-4-16 Yayoi, Bunkyo-Ku, Tokyo, 113-0032, Japan.

Our news journalists report that additional information may be obtained by contacting T. Yano, Toyo University, Grad Sch Food & Nutr Sci, Gunma 3740193, Japan. Additional authors for this research include S. Kaneko, K. Kohno, T. Yamazaki, K. Kato and A. Sato.

The direct object identifier (DOI) for that additional information is: This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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