Newswire (Published: Thursday, October 10, 2019, Received: Thursday, October 10, 2019, 6:28:07 PM CDT)

Word Count: 489

2019 OCT 10 (NewsRx) -- By a News Reporter-Staff News Editor at Disease Prevention Daily -- Current study results on Oncology - Prostate Cancer have been published. According to news reporting originating in Birmingham, Alabama, by NewsRx journalists, research stated, “Concerns about overtreatment of clinically indolent prostate cancer (PrCa) have led to recommendations that men who are diagnosed with low-risk PrCa be managed by active surveillance (AS) rather than immediate definitive treatment. However the risk of underestimating the aggressiveness of a patient’s PrCa can be a significant source of anxiety and a barrier to patient acceptance of AS.”

The news reporters obtained a quote from the research from the University of Alabama at Birmingham., “The uncertainty is particularly keen for African American (AA) men who are about 1.7 times more likely to be diagnosed with PrCa than European American (EA) men and about 2.4 times more likely to die of this disease. The AA population, as many other populations in the Americas, is genetically heterogeneous with varying degrees of admixture from West Africans (WAs), Europeans, and Native Americans (NAs). Recommendations for PrCa screening and management rarely consider potential differences in risk within the AA population. We compared WA genetic ancestry in AA men undergoing standard prostate biopsy who were diagnosed with no cancer, low-grade PrCa (Gleason Sum 6), or higher grade PrCa (Gleason Sum 7-10). We found that WA genetic ancestry was significantly higher in men who were diagnosed with PrCa on biopsy, compared to men who were cancer-negative, and highest in men who were diagnosed with higher grade PrCa (Gleason Sum 7-10).”

According to the news reporters, the research concluded: “Incorporating WA ancestry into the guidelines for making decisions about when to obtain a biopsy and whether to choose AS may allow AA men to personalize their approach to PrCa screening and management.”

For more information on this research see: Self-Identified African Americans and prostate cancer risk: West African genetic ancestry is associated with prostate cancer diagnosis and with higher Gleason sum on biopsy. Cancer Medicine, 2019;():. (Wiley-Blackwell - http://www.wiley.com/; Cancer Medicine - http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2045-7634)

Our news correspondents report that additional information may be obtained by contacting W.E. Grizzle, Dept. of Pathology and Surgery, University of Alabama at Birmingham., Birmingham, AL, United States. Additional authors for this research include R.A. Kittles, S. Rais-Bahrami, E. Shah, G.W. Adams, M.S. DeGuenther, P.N. Kolettis, J.W. Nix, J.E. Bryant, R. Chinsky, J.E. Kearns, K. Dehimer, N. Terrin, H. Chang and S.M Gaston.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1002/cam4.2434. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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