Newswire (Published: Thursday, May 9, 2019, Received: Thursday, May 9, 2019, 3:25:19 PM CDT)
Word Count: 566
2019 MAY 09 (NewsRx) -- By a
Prostate cancer is the most common male cancer in
A continued hormonal treatment for the mCRPC condition with drugs such as Zytiga (abiraterone acetate) and Xtandi (enzalutamide) provides additional clinical benefit, however not all patients respond to these treatments. Thus, in order to avoid unnecessary side effects and pharmaceutical expenses, it is necessary to identify those men who will benefit from the medicines before treatment is started.
This problem is now closer to being resolved through new results by researchers at Karolinska Institutet.
“Our method can identify patients who are likely to have a poor outcome to these treatments and therefore should be offered other alternatives, if available,” says lead author
The researchers’ methodology is based on an analysis of prognostic biomarkers, with known associations with therapy resistance, in the blood of patients with mCRPC.
In prostate cancer, treatment resistance can be caused by changes in genes such as the androgen receptor (AR) and a gene called TP53. Most often, these resistance markers have been studied on a one by one basis, which has led to conflicting results between independent scientific publications.
Instead, the researchers at Karolinska Institutet have developed a method for investigating all known resistance markers in AR and TP53 simultaneously. This was first done in a larger patient cohort, in a study published last year, where the researchers were able to show that individual markers in AR were not independently associated with outcome, when correcting for clinical characteristics, circulating tumour burden estimates and mutations in TP53.
They now show that in the subset of the patients without TP53 mutations, the number of AR resistance markers can indeed provide independent prognostic information.
“We see that the prognosis is poorest for men with three or more resistance markers in AR,” says
Consequently, the research group is introducing a new concept, the AR-burden - a measure of the number of treatment relevant changes in the AR gene.
The researchers are now working on improving their method of measurement and validating it retrospectively in patients recruited during the recently initiated ProBio clinical trial (NCT03903835).
“Our goal is to create a test that can be used routinely in clinical practice, so that patients can receive more personalised treatment,” says
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