Newswire (Published: Friday, June 14, 2019, Received: Friday, June 14, 2019, 5:43:53 PM CDT)
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2019 JUN 14 (NewsRx) -- By a
Interim analysis of the ANZUP-led international randomized, phase III ENZAMET trial demonstrated that among men with mHSPC who received testosterone suppression, those also given enzalutamide survived longer overall than those who were also given standard nonsteroidal androgen receptor inhibitors. Among trial participants, 80% of those treated with enzalutamide were alive after three years compared to 72% of the men who received the standard inhibitors.
“These findings are truly practice-informing, adding an effective drug option in treating mHSPC,” said study co-chair Sweeney who presented results during the ASCO plenary session. The plenary session features four studies deemed to have the greatest potential impact on patient care, out of more than 6,000 featured abstracts at the 5-day conference. The details were published simultaneously in the
“Adding enzalutamide to testosterone suppression in men with mHSPC can give much better cancer control and much longer survival,” said Sweeney. “This is true both for patients with high burden of disease, with multiple bone metastases or liver metastases, as well as men with a lower burden of disease. The new treatment option is especially relevant for men who cannot tolerate chemotherapy and have a lower burden of disease.”
“The benefits of enzalutamide had already been established for prostate cancers that are no longer responding to hormonal therapy,” said
One important question that the trial sought to understand was how well enzalutamide compared to, or combined with, docetaxel, a chemotherapy drug approved for the condition that was given to about 45% of trial participants. ENZAMET showed that in this population, “enzalutamide and docetaxel are both active and are reasonable alternatives but have different side effects, costs, risks and benefits,” Sweeney said.
Early analysis suggests that among men with a lower burden of metastatic disease given testosterone suppression, enzalutamide may offer more benefit than docetaxel, Sweeney said. However, he cautioned that this finding needs further investigation. Combining testosterone suppression with both enzalutamide and docetaxel delayed time for the disease to progress, but the researchers must follow up on trial participants to see if this triplet combination also improves quality of life and overall survival.
Overall in ENZAMET, side effects known to be associated with enzalutamide were observed and resulted in a modest increase in adverse events compared to men receiving one of the standard non-steroidal anti-androgens.
The remaining 5% of patients initially present with very aggressive disease, and many other patients relapse after treatment for localized disease but tend to have slower disease progression. The
ENZAMET is a collaborative investigator-initiated study led by the Australian and
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