Newswire (Published: Tuesday, December 17, 2019, Received: Tuesday, December 17, 2019, 6:09:19 PM CST)

Word Count: 506

2019 DEC 17 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Daily News -- Fresh data on Surgery - Prostatectomy are presented in a new report. According to news reporting from Heidelberg, Germany, by NewsRx journalists, research stated, “To analyze divergences between the planned and applied treatment doses for post-prostatectomy radiotherapy to the prostatic fossa on a voxel-by-voxel basis based on interfractional anatomic variations and imaging frequency. For 10 patients receiving intensity-modulated postoperative radiotherapy to the prostatic fossa, position verification was carried out by daily in-room CT imaging in treatment position (340 fraction CTs).”

The news correspondents obtained a quote from the research from German Cancer Research Center, “Applied fraction doses were recalculated on daily CT scans, and treatment doses were accumulated on a voxel-by-voxel basis after deformable image registration. To simulate weekly imaging, derived weekly position correction vectors were used to rigidly register all daily scans of the respective treatment week onto the planning CT before dose accumulation. Detailed dose statistics of the prescribed and applied treatment doses were compared in relation to the frequency of position verification imaging. Derived NTCP and P values were calculated for the rectum and bladder. Despite a large variability in the pelvic anatomy, daily CT-based patient repositioning resulted in largely negligible deviations of the analyzed dose-volume, conformity, and uniformity parameters from the planned doses for post-prostatectomy radiotherapy, and only the bladder exhibited significant increases in the accumulated mean and median doses. Derived NTCP for the applied doses to the rectum and bladder and P values did not significantly deviate from the treatment plan. In contrast, weekly CT-based repositioning resulted in significant decreases of the PTV coverage and dose conformity as well as large deviations of the applied doses to the rectum and bladder from the planned doses. Consecutively, NTCP for the rectum and P were found falsely reduced for weekly patient repositioning. Our data indicate for the first time in a voxel-by-voxel analysis that daily imaging is required for reliable adaptive delivery of intensity-modulated radiotherapy to the prostatic fossa.”

According to the news reporters, the research concluded: “This work will help guiding adaptive treatment strategies for post-prostatectomy radiotherapy.”

For more information on this research see: Dosimetric Impact of Interfractional Variations for Post-prostatectomy Radiotherapy to the Prostatic Fossa-Relevance for the Frequency of Position Verification Imaging and Treatment Adaptation. Frontiers In Oncology, 2019;9():1191.

Our news journalists report that additional information may be obtained by contacting M. Splinter, Medical Physics in Radiation Oncology, German Cancer Research Center, Heidelberg, Germany. Additional authors for this research include T. Bostel, I. Sachpazidis, T. Fechter, C. Zamboglou, O. Jakel, P.E. Huber, J. Debus, D. Baltas and N.H Nicolay.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.3389/fonc.2019.01191. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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