Newswire (Published: Tuesday, April 23, 2019, Received: Tuesday, April 23, 2019, 3:51:35 PM CDT)

Word Count: 377

2019 APR 23 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity Daily News -- Current study results on Oncology - Prostate Cancer have been published. According to news reporting out of Parkville, Australia, by NewsRx editors, research stated, “Prostate cancer is a leading cause of morbidity and cancer-related death worldwide. Androgen deprivation therapy (ADT) is the cornerstone of management for advanced disease.”

Our news journalists obtained a quote from the research from the Department of Surgery, “The use of these therapies is associated with multiple side effects, including metabolic syndrome and truncal obesity. At the same time, obesity has been associated with both prostate cancer development and disease progression, linked to its effects on chronic inflammation at a tissue level. The connection between androgen deprivation therapy, obesity, inflammation, and prostate cancer progression is well-established in clinical settings; however, an understanding of the changes in adipose tissue at the molecular level induced by castration therapies is missing. Here we investigated the transcriptional changes in periprostatic fat tissue induced by profound androgen deprivation therapy in a group of patients with high-risk tumours compared to a matching untreated cohort. We find that the deprivation of androgen is associated with a pro-inflammatory and obesity-like adipose tissue microenvironment.”

According to the news editors, the research concluded: “This study suggests that the beneficial effect of therapies based on androgen deprivation may be partially counteracted by metabolic and inflammatory side effects in the adipose tissue surrounding the prostate.”

For more information on this research see: Androgen deprivation therapy promotes an obesity-like microenvironment in periprostatic fat. Endocrine Connections, 2019;():.

Our news journalists report that additional information may be obtained by contacting S. Mangiola, S Mangiola, Dept. of Surgery, University of Melbourne, Parkville, Australia. Additional authors for this research include R. Stuchbery, P.J. McCoy, K. Chow, N. Kurganovs, M. Kerger, A.T. Papenfuss, C.M. Hovens and N.M Corcoran.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1530/ec-19-0029. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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