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  New Prostate Cancer Study Findings Have Been Reported by Investigators at Royal Adelaide Hospital  

Cancer Weekly (Published: Tuesday, April 15, 2014, Received: Thursday, April 10, 2014, 3:28:57 AM CDT)
Word Count: 451

By a News Reporter-Staff News Editor at Cancer Weekly -- A new study on Oncology is now available. According to news reporting from Adelaide, Australia, by NewsRx journalists, research stated, "Pelvic radiotherapy may lead to changes of anorectal function resulting in incontinence-related complaints. The aim of this study was to systematically review objective findings of late anorectal physiology and mucosal appearance after irradiation for prostate cancer."

The news correspondents obtained a quote from the research from Royal Adelaide Hospital, "MEDLINE, EMBASE, and the Cochrane library were searched. Original articles in which anal function, rectal function, or rectal mucosa were examined a parts per thousand yen3 months after EBRT for prostate cancer were included. Twenty-one studies were included with low to moderate quality. Anal resting pressures significantly decreased in 6 of the 9 studies including 277 patients. Changes of squeeze pressure and rectoanal inhibitory reflex were less uniform. Rectal distensibility was significantly impaired after EBRT in 7 of 9 studies (277 patients). In 4 of 9 studies on anal and in 5 of 9 on rectal function, disturbances were associated with urgency, frequent bowel movements or fecal incontinence. Mucosal changes as assessed by the Vienna Rectoscopy Score revealed telangiectasias in 73 %, congestion in 33 %, and ulceration in 4 % of patients in 8 studies including 346 patients, but no strictures or necrosis. Three studies reported mucosal improvement during follow-up. Telangiectasias, particularly multiple, were associated with rectal bleeding. Not all bowel complaints (30 %) were related to radiotherapy. Low to moderate quality evidence indicates that EBRT reduces anal resting pressure, decreases rectal distensibility, and frequently induces telangiectasias of rectal mucosa."

According to the news reporters, the research concluded: "Objective changes may be associated with fecal incontinence, urgency, frequent bowel movements, and rectal bleeding, but these symptoms are not always related to radiation damage."

For more information on this research see: Systematic review: anal and rectal changes after radiotherapy for prostate cancer. International Journal of Colorectal Disease, 2014;29(3):273-283. International Journal of Colorectal Disease can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; International Journal of Colorectal Disease - www.springerlink.com/content/0179-1958/)

Our news journalists report that additional information may be obtained by contacting R. Krol, Royal Adelaide Hospital, Dept. of Radiat Oncol, Adelaide, SA 5000, Australia. Additional authors for this research include R.J. Smeenk, E. van Lin, E.E.K. Yeoh and W.P.M. Hopman (see also Oncology).

Keywords for this news article include: Urology, Adelaide, Oncology, Incontinence, Radiotherapy, Prostate Cancer, Gastroenterology, Prostatic Neoplasms, Australia and New Zealand

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

(c) 2014 Cancer Weekly via NewsRx.com
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