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  Findings on Clinical Trials and Studies Discussed by Investigators at University of Gothenburg  
 

Clinical Trials Week (Published: Monday, April 14, 2014, Received: Wednesday, April 9, 2014, 7:10:59 PM CDT)
Clinical Research
Word Count: 454
 

By a News Reporter-Staff News Editor at Clinical Trials Week -- Fresh data on Clinical Research are presented in a new report. According to news reporting from Gothenburg, Sweden, by NewsRx journalists, research stated, "To compare the survival outcomes of patients treated with surgery or radiotherapy for prostate cancer. Observational study. Sweden, 1996-2010. Participants 34 515 men primarily treated for prostate cancer with surgery (n=21 533) or radiotherapy (n=12 982)."

The news correspondents obtained a quote from the research from the University of Gothenburg, "Patients were categorised by risk group (low, intermediate, high, and metastatic), age, and Charlson comorbidity score. Cumulative incidence of mortality from prostate cancer and other causes. Competing risks regression hazard ratios for radiotherapy versus surgery were computed without adjustment and after propensity score and traditional (multivariable) adjustments, as well as after propensity score matching. Several sensitivity analyses were performed. Prostate cancer mortality became a larger proportion of overall mortality as risk group increased for both the surgery and the radiotherapy cohorts. Among patients with non-metastatic prostate cancer the adjusted subdistribution hazard ratio for prostate cancer mortality favoured surgery (1.76, 95% confidence interval 1.49 to 2.08, for radiotherapy v prostatectomy), whereas there was no discernible difference in treatment effect among men with metastatic disease. Subgroup analyses indicated more clear benefits of surgery among younger and fitter men with intermediate and high risk disease. Sensitivity analyses confirmed the main findings. This large observational study with follow-up to 15 years suggests that for most men with non-metastatic prostate cancer, surgery leads to better survival than does radiotherapy."

According to the news reporters, the research concluded: "Younger men and those with less comorbidity who have intermediate or high risk localised prostate cancer might have a greater benefit from surgery."

For more information on this research see: Comparative effectiveness of radical prostatectomy and radiotherapy in prostate cancer: observational study of mortality outcomes. BMJ-British Medical Journal, 2014;348():1-13. BMJ-British Medical Journal can be contacted at: Bmj Publishing Group, British Med Assoc House, Tavistock Square, London WC1H 9JR, England (see also Clinical Research).

Our news journalists report that additional information may be obtained by contacting P. Sooriakumaran, University of Gothenburg, Sahlgrenska Academy, Inst Clin Sci, Div Clin Canc EpidemiolDept Oncol, Gothenburg, Sweden. Additional authors for this research include T. Nyberg, O. Akre, L. Haendler, I. Heus, M. Olsson, S. Carlsson, M.J. Roobol, G. Steineck and P. Wiklund.

Keywords for this news article include: Sweden, Europe, Surgery, Oncology, Gothenburg, Radiotherapy, Prostatectomy, Prostate Cancer, Clinical Research, Prostatic Neoplasms, Clinical Trials and Studies, Male Urologic Surgical Procedures

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

 
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