Newswire (Published: Tuesday, May 8, 2018, Received: Thursday, May 3, 2018, 5:45:34 PM CDT)

Word Count: 510

Researchers at University of Montreal Have Reported New Data on Prostate Cancer (Tumor characteristics, treatments, and oncological outcomes of prostate cancer in men aged <= 50 years: a population-based study)

By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators discuss new findings in Oncology - Prostate Cancer. According to news reporting from Montreal, Canada, by NewsRx journalists, research stated, "To examine clinical characteristics, treatment modalities and oncological outcomes of prostate cancer (PCa) according to young (<= 50) vs. old age. Of 407,599 men with primary adenocarcinoma of the prostate within the Surveillance, Epidemiology and End Results (SEER)-database (2004 to 2013), 18,387 were aged <= 50 years (4.5%)."

The news correspondents obtained a quote from the research from the University of Montreal, "Time trends, cumulative incidence, and competing risks regression (CRR) analyses tested for differences between young and old patients. Multi-variable analyses were adjusted for year of diagnosis, race, marital status, Gleason Score, clinical tumor stage, and lymph node status. Younger men had more favorable tumor characteristics: lower Gleason Score, lower median PSA, and lower rates of metastases at diagnosis compared to their older counterparts. Over time, no local treatment (NLT) rates increased, radical prostatectomy (RP), and brachytherapy (BT) rates decreased and external beam radiation (EBRT) rates remained unchanged. Moreover, the rate of de novo metastatic prostate cancer increased in young patients from 2% (2004) to 3.2% (2013) (p = 0.004). CRR models showed no difference in prostate cancer-specific mortality (PCSM) between young and old, across all local treatment types. Young PCa patients have more favorable disease characteristics at presentation, are less frequently treated with RP or BT and more frequently benefit of NLT. PCSM did not differ between young and old patients."

According to the news reporters, the research concluded: "However, it is worrisome that recently more young PCa patients are diagnosed at a metastatic stage."

For more information on this research see: Tumor characteristics, treatments, and oncological outcomes of prostate cancer in men aged <= 50 years: a population-based study. Prostate Cancer and Prostatic Diseases, 2018;21(1):71-77. Prostate Cancer and Prostatic Diseases can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - www.nature.com/; Prostate Cancer and Prostatic Diseases - www.nature.com/pcan/)

Our news journalists report that additional information may be obtained by contacting R.S. Pompe, University of Montreal, Hlth Center, Canc Prognost & Hlth Outcomes Unit, Montreal, PQ, Canada. Additional authors for this research include A. Smith, M. Bandini, M. Marchioni, T. Martel, F. Preisser, S.R. Leyh-Bannurah, J. Schiffmann, F. Saad, H. Huland, M. Graefen, S.F. Shariat, D. Tilki and P.I. Karakiewicz (see also Oncology - Prostate Cancer).

Keywords for this news article include: Montreal, Quebec, Canada, North and Central America, Health and Medicine, Prostatic Neoplasms, Prostate Cancer, Epidemiology, Oncology, University of Montreal.

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