Newswire (Published: Tuesday, July 4, 2017, Received: Thursday, June 29, 2017, 1:58:41 PM CDT)

Word Count: 567

Investigators at Asan Medical Center Report Findings in Prostate Cancer (Obesity as a Risk Factor for Unfavorable Disease in Men with Low Risk Prostate Cancer and its Relationship with Anatomical Location of Tumor)

By a News Reporter-Staff News Editor at Cancer Weekly -- Data detailed on Oncology - Prostate Cancer have been presented. According to news reporting originating from Seoul, South Korea, by NewsRx correspondents, research stated, "We investigated the influence of obesity on unfavorable disease in men with low risk prostate cancer eligible for active surveillance and verified the underlying relationship with tumor location. We analyzed the records of 890 patients with biopsy Gleason score 6 who underwent radical prostatectomy for prostate cancer via multicore (12 or more) biopsy at our institution."

Our news editors obtained a quote from the research from Asan Medical Center, "Unfavorable disease was defined as primary Gleason pattern 4 or greater, or pathological stage T3 or greater. Multivariate logistic regression analysis was performed to identify factors associated with unfavorable disease. The association of unfavorable disease with anatomical location of the index tumor was assessed. Overall 216 (24.3%), 544 (61.1%) and 130 men (14.6%) had a body mass index of less than 23 (normal), 23 to 27.5 (overweight) and 27.5 kg/m(2) or greater (obese), respectively, according to established cutoff points for Asian men. Multivariate analysis showed that age, prostate volume and body mass index were independent factors for predicting unfavorable disease regardless of the various active surveillance criteria used. For Johns Hopkins Hospital criteria the risk of unfavorable disease was higher in obese patients than in normal weight patients (OR 3.30, p = 0.022). Unfavorable disease was more frequent in cases of transition zone cancer than nontransition zone cancer across all criteria for active surveillance (all p< 0.01). Among men fulfilling Johns Hopkins Hospital criteria the proportion of transition zone cancer was 4.2% for normal weight, 11.6% for overweight and 16.7% for obesity, respectively (p = 0.022). Obese men with low risk prostate cancer who are eligible for active surveillance are at higher risk for unfavorable pathological features."

According to the news editors, the research concluded: "Obese men more frequently had transition zone cancer, which was associated with unfavorable pathology findings in those with very low risk prostate cancer."

For more information on this research see: Obesity as a Risk Factor for Unfavorable Disease in Men with Low Risk Prostate Cancer and its Relationship with Anatomical Location of Tumor. Journal of Urology, 2017;198(1):71-78. Journal of Urology can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier - www.elsevier.com; Journal of Urology - www.journals.elsevier.com/journal-of-urology/)

The news editors report that additional information may be obtained by contacting C.S. Kim, Asan Med Center, Dept. of Urol, Seoul 138736, South Korea. Additional authors for this research include S. Yoo, C. Lee, M. Kim, D. You, C. Song, S. Park, J.H. Hong, H. Ahn and I.G. Jeong (see also Oncology - Prostate Cancer).

Keywords for this news article include: Seoul, South Korea, Asia, Nutritional and Metabolic Diseases and Conditions, Risk and Prevention, Epidemiology, Nutrition Disorders, Prostatic Neoplasms, Diet and Nutrition, Prostate Cancer, Overnutrition, Bariatrics, Hospital, Oncology, Obesity, Asan Medical Center.

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