Newswire (Published: Monday, April 10, 2017, Received: Friday, April 7, 2017, 6:52:49 AM CDT)

Word Count: 448

New Findings on Prostate Cancer from H.D. Zacho and Co-Authors Summarized (Unexplained Bone Pain Is an Independent Risk Factor for Bone Metastases in Newly Diagnosed Prostate Cancer: A Prospective Study)

By a News Reporter-Staff News Editor at Clinical Trials Week -- A new study on Oncology - Prostate Cancer is now available. According to news reporting out of Randers, Denmark, by NewsRx editors, research stated, "To determine the relationship between bone pain and bone metastases in newly diagnosed prostate cancer. This prospective study of bone scintigraphy enrolled 567 consecutive patients with newly diagnosed prostate cancer."

Our news journalists obtained a quote from the research, "The presence of all cause bone pain, known benign bone disease, and unexplained bone pain (ie, not related to known benign bone disease) was derived from a patient questionnaire. Univariate logistic regression models (LRMs) were used to assess the relationship between individual clinical variables (all-cause bone pain, unexplained bone pain, prostate-specific antigen, Gleason grade, T stage, and age) and bone metastases. A multivariate LRM was used to assess the relationship between bone metastases and all factors in combination. Agreement between the LRMs and bone metastases was estimated by accuracy and by Cohen's.. All-cause bone pain predicted bone metastasis in univariate but not multivariate analysis. Unexplained bone pain remained an independent predictor of bone metastases in multivariate analysis (odds ratio: 4.5; P< .001). Prostate-specific antigen was the single most important predictor of bone metastases (P < .001). Unexplained bone pain was a strong independent risk factor for bone metastasis."

According to the news editors, the research concluded: "Guidelines should recommend staging bone scintigraphy in patients with unexplained bone pain, regardless of other risk factors."

For more information on this research see: Unexplained Bone Pain Is an Independent Risk Factor for Bone Metastases in Newly Diagnosed Prostate Cancer: A Prospective Study. Urology, 2017;99():148-154. Urology can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier - www.elsevier.com; Urology - www.journals.elsevier.com/urology/)

Our news journalists report that additional information may be obtained by contacting H.D. Zacho, Randers Cent Hosp, Dept. of Clin Physiol & Nucl Med, Randers, Denmark. Additional authors for this research include C.D. Morch, T. Barsi, J.C. Mortensen, H. Bertelsen and L.J. Petersen (see also Oncology - Prostate Cancer).

Keywords for this news article include: Randers, Denmark, Europe, Risk and Prevention, Diagnostics and Screening, Musculoskeletal Diseases and Conditions, Bone Diseases and Conditions, Clinical Trials and Studies, Prostatic Neoplasms, Clinical Research, Prostate Cancer, Bone Research, Oncology.

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