Newswire (Published: Friday, February 24, 2017, Received: Thursday, February 16, 2017, 1:57:46 PM CST)

Word Count: 522

Findings from Sidney Kimmel Comprehensive Cancer Center Broaden Understanding of Prostate Cancer (Sequencing Treatment for Castration-Resistant Prostate Cancer)

By a News Reporter-Staff News Editor at Drug Week -- Research findings on Oncology - Prostate Cancer are discussed in a new report. According to news reporting originating from Baltimore, Maryland, by NewsRx correspondents, research stated, "Prostate cancer is the most common non-cutaneous cancer diagnosed in men and the second leading cause of male cancer deaths in the USA. While most cases are diagnosed in early stages, some will present as or progress to metastatic disease and eventually castration-resistant prostate cancer (mCRPC) which has a mortality rate exceeding 50 %. There are currently six approved systemic life-prolonging therapies for use in mCRPC, yet little data to guide sequencing."

Our news editors obtained a quote from the research from Sidney Kimmel Comprehensive Cancer Center, "Clinical factors, including the presence or absence of symptoms and the presence or absence of visceral metastases, should help determine the best therapeutic choice at each treatment node. Those with asymptomatic bone-only disease could be considered for sipuleucel-T, abiraterone, enzalutamide, or docetaxel in the first-line setting. For symptomatic disease, docetaxel could be used or radium-223 if disease is only present in the bone. In the second-line setting, sipuleucel-T or radium-223 can be used in the appropriate clinical setting. Taxane chemotherapy could be used if a novel androgen-directed therapy was used in the first-line setting. Cabazitaxel, if docetaxel was previously used, should be considered. There is scarce data on best treatment options in the third-line setting. In general, we recommend alternating between androgen-targeting agents and taxane chemotherapy. Finally, consideration should be given to testing for the androgen receptor splice variant AR-V7, which may be a relevant treatment-specific biomarker to aid in the selection of androgen-targeting therapy versus chemotherapy at each treatment juncture. Mutation testing for DNA damage repair defects can also be considered, as such patients may benefit from investigational poly ADP ribose polymerase (PARP) inhibitors or platinum-based chemotherapies."

According to the news editors, the research concluded: "Several ongoing studies have been designed to answer some of these sequencing questions, including the biomarker questions, and will hopefully continue to inform us about rational therapy selection in mCRPC."

For more information on this research see: Sequencing Treatment for Castration-Resistant Prostate Cancer. Current Treatment Options in Oncology, 2016;17(12):59-73. Current Treatment Options in Oncology can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Current Treatment Options in Oncology - www.springerlink.com/content/1527-2729/)

The news editors report that additional information may be obtained by contacting E.S. Antonarakis, Johns Hopkins, Sidney Kimmel Comprehens Canc Center, Baltimore, MD 21287, United States (see also Oncology - Prostate Cancer).

Keywords for this news article include: Baltimore, Maryland, United States, North and Central America, Bone Research, Article Review, Diagnostics and Screening, Drugs and Therapies, Prostatic Neoplasms, Mitotic Inhibitors, Docetaxel Therapy, Antineoplastics, Pharmaceuticals, Prostate Cancer, Chemotherapy, Androgens, Oncology, Genetics, Sidney Kimmel Comprehensive Cancer Center.

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