Newswire (Published: Monday, December 11, 2017, Received: Thursday, December 7, 2017, 6:37:25 PM CST)

Word Count: 511

Study Findings on Prostate Cancer Are Outlined in Reports from Department of Surgery (68Ga-prostate-specific membrane antigen-positron emission tomography/computed tomography in advanced prostate cancer: Current state and future trends)

By a News Reporter-Staff News Editor at Clinical Trials Week -- Investigators publish new report on Oncology - Prostate Cancer. According to news originating from Melbourne, Australia, by NewsRx correspondents, research stated, "The early and accurate detection of prostate cancer is important to ensure timely management and appropriate individualized treatment. Currently, conventional imaging has limitations particularly in the early detection of metastases and at prostate-specific antigen (PSA) levels? <?2.0?ng/mL."

Our news journalists obtained a quote from the research from the Department of Surgery, "Furthermore, disease management such as salvage radiotherapy is best at low PSA levels. Thus, it is critical to capture the disease in the oligometastatic stage as disease progression and commencement of systemic therapies can be delayed by metastasis-directed therapy. Prostate-specific membrane antigen (PSMA) is overexpressed in prostatic cancer cells. Novel imaging modalities using radiolabeled tracers with PSMA such as Ga-PSMA-positron emission tomography (PET)/computed tomography (CT) have shown promising results. We review the literature regarding Ga-PSMA-PET/CT in the setting of primary prostate cancer and biochemical recurrence. At present, the best utilization of Ga-PSMA-PET/CT appears to be in biochemical recurrence. Ga-PSMA-PET/CT has high diagnostic accuracy for lymph node metastases and has been shown to have superior detection rates to conventional imaging, especially at low PSA levels. The exact role of Ga-PSMA-PET/CT in primary prostate cancer is not yet entirely clear. It has an improved detection rate for smaller lesions and may be able to identify nodal or distant metastatic disease at an earlier stage. While still experimental, there may also be value in combining Ga-PSMA-PET to multiparametric magnetic resonance imaging for staging of intraprostatic disease. To date, Ga-PSMA-PET/CT has been shown to have considerable clinical value and to impact treatment selection for patients with prostate cancer."

According to the news editors, the research concluded: "Still in its infancy, the results of future clinical trials will be excitedly awaited."

For more information on this research see: 68Ga-prostate-specific membrane antigen-positron emission tomography/computed tomography in advanced prostate cancer: Current state and future trends. Prostate International, 2017;5(4):125-129 (see also Oncology - Prostate Cancer).

The news correspondents report that additional information may be obtained from C. Udovicich, Dept. of Surgery, Mildura Base Hospital, Melbourne, Australia. Additional authors for this research include M. Perera, M.S. Hofman, S. Siva, A. Del Rio, D.G. Murphy and N. Lawrentschuk.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.prnil.2017.02.003. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Oncology, Melbourne, Biochemicals, Biochemistry, Article Review, Prostate Cancer, Imaging Technology, Computed Tomography, Prostatic Neoplasms, Enzymes and Coenzymes, Australia and New Zealand, Prostate Specific Antigen.

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