Newswire (Published: Tuesday, March 14, 2017, 12:01:00 AM CDT, Received: Thursday, March 9, 2017, 7:17:27 PM CST)

Word Count: 429

Reports Outline Prostate Cancer Study Results from Osaka University Graduate School of Medicine (Decreased fucosylated PSA as a urinary marker for high Gleason score prostate cancer)

By a News Reporter-Staff News Editor at Cancer Weekly -- Researchers detail new data in Oncology - Prostate Cancer. According to news originating from Suita, Japan, by NewsRx correspondents, research stated, "Fucosylation is an important oligosaccharide modification associated with cancer and inflammation. We investigated whether urinary fucosylated PSA (Fuc-PSA) levels could be used for the detection of high Gleason score prostate cancer."

Our news journalists obtained a quote from the research from the Osaka University Graduate School of Medicine, "Urine samples were collected from men with abnormal digital rectal examination findings or elevated serum PSA levels, before prostate biopsy. Lectin-antibody ELISA was used to quantify the Lewis-type or core-type fucosylated PSA (PSA-AAL) and core-type fucosylated PSA (PSA-PhoSL) in the urine samples. Both types of urinary Fuc-PSA were significantly decreased in the men with prostate cancer compared with the men whose biopsies were negative for cancer (p=0.026 and p<0.001, respectively). Both were also significantly associated with the Gleason scores of the biopsy specimens (p=0.001 and p<0.001, respectively). Multivariate analysis showed that PSA density, urinary PSA-AAL, and urinary PSA-PhoSL were independent predictors of high Gleason score prostate cancer. The area under the receiver-operator characteristic curve (AUC) value for the prediction of cancers of Gleason score greater than or equal to 7 was 0.69 for urinary PSA-AAL and 0.72 for urinary PSA-PhoSL. In contrast, the AUC value was 0.59 for serum PSA, 0.63 for PSA density, and 0.58 for urinary PSA."

According to the news editors, the research concluded: "A decreased urinary Fuc-PSA level is a potential marker for the detection of high Gleason score prostate cancer."

For more information on this research see: Decreased fucosylated PSA as a urinary marker for high Gleason score prostate cancer. Oncotarget, 2016;7(35):56643-56649 (see also Oncology - Prostate Cancer).

The news correspondents report that additional information may be obtained from K. Fujita, Dept. of Urology, Osaka University Graduate School of Medicine, Suita, Japan. Additional authors for this research include T. Hayashi, K. Matsuzaki, W. Nakata, M. Masuda, A. Kawashima, T. Ujike, A. Nagahara, M. Tsuchiya, Y. Kobayashi, S. Nojima, M. Uemura, E. Morii, E. Miyoshi and N. Nonomura.

Keywords for this news article include: Asia, Suita, Japan, Oncology, Prostate Cancer, Prostatic Neoplasms.

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