Newswire (Published: Tuesday, March 14, 2017, 12:01:00 AM CDT, Received: Thursday, March 9, 2017, 6:49:09 PM CST)

Word Count: 447

Researchers from Appalachian State University Describe Findings in Prostate Cancer (Curcumin promotes the oncoltyic capacity of vesicular stomatitis virus for the treatment of prostate cancers)

By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Oncology - Prostate Cancer have been published. According to news reporting originating from Boone, North Carolina, by NewsRx correspondents, research stated, "Vesicular stomatitis virus (VSV) matrix (M) protein mutants have been studied as oncolytic agents due to their capacity to effectively kill cancer cells while exhibiting low virulence in vivo. Despite encouraging results, many cancer cells maintain resistance to oncolytic VSV mutants in part due to residual antiviral responses."

Financial support for this research came from Appalachian State University (see also Oncology - Prostate Cancer).

Our news editors obtained a quote from the research from Appalachian State University, "We sought to determine whether combination of VSV with natural agents with anti-tumor properties, such as curcumin, resveratrol, and flavokavain B, would enhance tumor cell killing in a prostate cancer model. Our results revealed that pretreatment with curcumin potentiated VSV-induced oncolysis of PC-3 prostate cancer cells in cell culture and in a mouse model of prostate cancer. The ability of curcumin to synergize with VSV in PC-3 cells correlated with a cumulative decrease in the expression of the anti-apoptotic protein, Bcl-xl, and in the phosphorylation of NF-kappa B. Although curcumin did not impact the expression of type I IFN in infected cells, it inhibited the phosphorylation and activation of STAT1, a key player in the IFN response pathway, leading to an overall increase in virus-infected cells."

According to the news editors, the research concluded: "These results suggest that curcumin sensitizes prostate cancer cells to the oncolytic effects of VSV by modulating antiviral responses and components of the intrinsic apoptotic pathway."

For more information on this research see: Curcumin promotes the oncoltyic capacity of vesicular stomatitis virus for the treatment of prostate cancers. Virus Research, 2017;228():14-23. Virus Research can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Virus Research - www.journals.elsevier.com/virus-research/)

The news editors report that additional information may be obtained by contacting M. Ahmed, Appalachian State University, Dept. of Biol, Boone, NC 28608, United States.

Keywords for this news article include: Boone, North Carolina, United States, North and Central America, Stomatognathic Diseases and Conditions, Animal Diseases and Conditions, Mouth Diseases and Conditions, Vesicular Stomatitis, Prostatic Neoplasms, Organic Chemicals, Diarylheptanoids, Prostate Cancer, Hydrocarbons, Catechols, Oncology, Curcumin, Alkanes, Appalachian State University.

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