Newswire (Published: Tuesday, February 7, 2017, Received: Thursday, February 2, 2017, 8:10:25 PM CST)

Word Count: 514

Research Conducted at Johns Hopkins University School of Medicine Has Updated Our Knowledge about Prostate Cancer (Unscreened older men diagnosed with prostate cancer are at increased risk of aggressive disease)

By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators discuss new findings in Oncology - Prostate Cancer. According to news reporting originating from Baltimore, Maryland, by NewsRx correspondents, research stated, "To evaluate the relationship between PSA testing history and high-risk disease among older men diagnosed with prostate cancer. Records from 1993 to 2014 were reviewed for men who underwent radiotherapy for prostate cancer at age 75 years or older."

Our news editors obtained a quote from the research from the Johns Hopkins University School of Medicine, "Patients were classified into one of four groups based on PSA-testing history: (1) no PSA testing; (2) incomplete/ineffective PSA testing; (3) PSA testing; or (4) cannot be determined. Outcomes of interest were National Comprehensive Cancer Network (NCCN) risk group (that is, low, intermediate or high risk) and biopsy grade at diagnosis. Multivariable logistic regression was used to determine the association between PSA testing history and high-risk cancer. PSA-testing history was available in 274 (94.5%) of 290 subjects meeting study criteria. In total, 148 men (54.0%) underwent PSA testing with follow-up biopsy, 72 (26.3%) underwent PSA testing without appropriate follow-up, and 54 men (19.7%) did not undergo PSA testing. Patients who underwent PSA testing were significantly less likely to be diagnosed with NCCN high-risk cancer (23.0% vs 51.6%, p<0.001). On multivariable analysis, men with no/incomplete PSA testing had more than three-fold increased odds of high-risk disease at diagnosis (odds ratio 3.39, 95% confidence interval 1.96-5.87, p<0.001) as compared to the tested population. Older men who underwent no PSA testing or incomplete testing were significantly more likely to be diagnosed with high-risk prostate cancer than those who were previously screened."

According to the news editors, the research concluded: "It is reasonable to consider screening in healthy older men likely to benefit from early detection and treatment.Prostate Cancer and Prostatic Diseases advance online publication, 3 January."

For more information on this research see: Unscreened older men diagnosed with prostate cancer are at increased risk of aggressive disease. Prostate Cancer and Prostatic Diseases, 2017;():. (Nature Publishing Group -; Prostate Cancer and Prostatic Diseases -

The news editors report that additional information may be obtained by contacting J.J. Tosoian, The James Buchanan Brady Urological Institute and Dept. of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, United States. Additional authors for this research include R. Alam, C. Gergis, A. Narang, N. Radwan, S. Robertson, T. McNutt, A.E. Ross, D.Y. Song, T.L. DeWeese, P.T. Tran and P.C Walsh (see also Oncology - Prostate Cancer).

Keywords for this news article include: Maryland, Oncology, Baltimore, United States, Prostate Cancer, Prostatic Neoplasms, North and Central America, Diagnostics and Screening.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC


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