Newswire (Published: Tuesday, February 7, 2017, Received: Thursday, February 2, 2017, 12:59:01 PM CST)

Word Count: 411

New Prostate Cancer Study Findings Have Been Reported from Beckman Research Institute (Gene Expression Differences in Prostate Cancers between Young and Old Men)

By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Oncology - Prostate Cancer have been published. According to news reporting out of Duarte, California, by NewsRx editors, research stated, "Prostate cancer incidence is increasing in younger men. We investigated whether men diagnosed with Gleason 7 (3+4) T2 prostate cancer at younger ages ( less than or equal to 45 years, young cohort) had different mRNA and miRNA expression profiles than men diagnosed at older ages (71-74 years, older cohort)."

Funders for this research include The Morris and Horowitz Families Professorship, National Cancer Institute of the National Institutes of Health (see also Oncology - Prostate Cancer).

Our news journalists obtained a quote from the research from Beckman Research Institute, "We identified differentially expressed genes (DEGs) related to tumor-normal differences between the cohorts. Subsequent pathway analysis of DEGs revealed that the young cohort had significantly more pronounced inflammatory and immune responses to tumor development compared to the older cohort. Further supporting a role of inflammation-induced immune-suppression in the development of early-onset prostate cancer, we observed significant up-regulation of CTLA4 and IDO1/TDO2 pathways in tumors of the young cohort. Moreover, over-expression of CTLA4 and IDO1 was significantly associated with biochemical recurrence."

According to the news editors, the research concluded: "Our results provide clues on the mechanisms of tumor development and point to potential biomarkers for early detection and treatment for prostate cancer in young men."

For more information on this research see: Gene Expression Differences in Prostate Cancers between Young and Old Men. Plos Genetics, 2016;12(12):e1006477. (Public Library of Science -; Plos Genetics -

Our news journalists report that additional information may be obtained by contacting Y. Ding, Dept. of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, United States. Additional authors for this research include H. Wu, C. Warden, L. Steele, X. Liu, M.V. Iterson, X. Wu, R. Nelson, Z. Liu, Y.C. Yuan and S.L Neuhausen.

Keywords for this news article include: Duarte, Genetics, Oncology, California, United States, Prostate Cancer, Prostatic Neoplasms, North and Central America, Diagnostics and Screening.

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