Newswire (Published: Tuesday, February 7, 2017, Received: Thursday, February 2, 2017, 11:26:02 PM CST)

Word Count: 498

Reports Outline Prostate Cancer Findings from University of California (Differential expression of miR-34b and androgen receptor pathway regulate prostate cancer aggressiveness between African-Americans and Caucasians)

By a News Reporter-Staff News Editor at Cancer Weekly -- New research on Oncology - Prostate Cancer is the subject of a report. According to news reporting originating in San Francisco, California, by NewsRx journalists, research stated, "African-Americans are diagnosed with more aggressive prostate cancers and have worse survival than Caucasians, however a comprehensive understanding of this health disparity remains unclear. To clarify the mechanisms leading to this disparity, we analyzed the potential involvement of miR-34b expression in African-Americans and Caucasians. miR-34b functions as a tumor suppressor and has a multi-functional role, through regulation of cell proliferation, cell cycle and apoptosis."

The news reporters obtained a quote from the research from the University of California, "We found that miR-34b expression is lower in human prostate cancer tissues from African-Americans compared to Caucasians. DNA hypermethylation of the miR-34b-3p promoter region showed significantly higher methylation in prostate cancer compared to normal samples. We then sequenced the promoter region of miR-34b-3p and found a chromosomal deletion in miR-34b in African-American prostate cancer cell line (MDA-PCA-2b) and not in Caucasian cell line (DU-145). We found that AR and ETV1 genes are differentially expressed in MDA-PCa-2b and DU-145 cells after overexpression of miR-34b. Direct interaction of miR-34b with the 3' untranslated region of AR and ETV1 was validated by luciferase reporter assay. We found that miR-34b downregulation in African-Americans is inversely correlated with high AR levels that lead to increased cell proliferation. Overexpression of miR-34b in cell lines showed higher inhibition of cell proliferation, apoptosis and G1 arrest in the African-American cells (MDA-PCa-2b) compared to Caucasian cell line (DU-145)."

According to the news reporters, the research concluded: "Taken together, our results show that differential expression of miR-34b and AR are associated with prostate cancer aggressiveness in African-Americans."

For more information on this research see: Differential expression of miR-34b and androgen receptor pathway regulate prostate cancer aggressiveness between African-Americans and Caucasians. Oncotarget, 2016;(): (see also Oncology - Prostate Cancer).

Our news correspondents report that additional information may be obtained by contacting M. Shiina, Dept. of Urology, Veterans Affairs Medical Center, San Francisco and University of California San Francisco, San Francisco, California, United States. Additional authors for this research include Y. Hashimoto, T. Kato, S. Yamamura, Y. Tanaka, S. Majid, S. Saini, S. Varahram, P. Kulkarni, P. Dasgupta, Y. Mitsui, M. Sumida, L. Tabatabai, G. Deng, D. Kumar and R. Dahiya.

Keywords for this news article include: Genetics, Oncology, Cell Line, California, San Francisco, United States, Prostate Cancer, Steroid Receptors, Androgen Receptors, Cell Proliferation, Prostatic Neoplasms, DNA Binding Proteins, Transcription Factors, North and Central America.

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