Newswire (Published: Tuesday, May 30, 2017, Received: Thursday, May 25, 2017, 5:09:04 PM CDT)

Word Count: 406

Recent Findings from W.N. Brennen and Co-Researchers Yields New Information on Prostate Cancer (Mesenchymal stem cell infiltration during neoplastic transformation of the human prostate)

By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators publish new report on Oncology - Prostate Cancer. According to news reporting out of Baltimore, Maryland, by NewsRx editors, research stated, "Mesenchymal Stem Cells (MSCs) have been identified in prostate cancer, raising the critical question of their physical and temporal source. Therefore, MSCs were quantified and characterized in benign and malignant prostate tissue representing different disease states and a wide range of age groups from fetal development through adult death using analytical and functional methodologies."

Our news journalists obtained a quote from the research, "In contrast to lineage-restricted Mesenchymal Progenitor Cells (MPCs) found in normal prostate tissue, MSCs with tri-lineage differentiation potential (adipogenesis, osteogenesis, and chondrogenesis) are identified in prostate tissue from a subset of men with prostate cancer, consistent with an influx of more stem-like progenitors (i.e. MSCs) from the bone marrow. Additionally, prostate tissue from a subset of these patients is highly enriched in MSCs, suggesting their enumeration may have prognostic value for identifying men with aggressive disease. This influx is an ongoing process continuing throughout disease progression as documented by the presence of MSCs in metastatic lesions from multiple organ sites harvested at the time of death in metastatic castration-resistant prostate cancer (mCRPC) patients."

According to the news editors, the research concluded: "This infiltration of MSCs from systemic circulation provides the rationale for their use as a cell-based vector to deliver therapeutic agents."

For more information on this research see: Mesenchymal stem cell infiltration during neoplastic transformation of the human prostate. Oncotarget, 2017;(): (see also Oncology - Prostate Cancer).

Our news journalists report that additional information may be obtained by contacting W.N. Brennen, Dept. of Oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, United States. Additional authors for this research include B. Zhang, I. Kulac, L.N. Kisteman, L. Antony, H. Wang, A.K. Meeker, A.M. De Marzo, I.P. Garraway, S.R. Denmeade and J.T Isaacs.

Keywords for this news article include: Maryland, Oncology, Baltimore, United States, Prostate Cancer, Stem Cell Research, Prostatic Neoplasms, Mesenchymal Stem Cells, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC


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