Newswire (Published: Tuesday, May 2, 2017, Received: Thursday, April 27, 2017, 8:56:33 PM CDT)

Word Count: 485

New Prostate Cancer Data Have Been Reported by Investigators at Osaka University (Disruption of collagen/apatite alignment impairs bone mechanical function in osteoblastic metastasis induced by prostate cancer)

By a News Reporter-Staff News Editor at Cancer Weekly -- New research on Oncology - Prostate Cancer is the subject of a report. According to news reporting originating in Osaka, Japan, by NewsRx journalists, research stated, "Prostate cancer (PCa) frequently metastasizes to the bone, generally inducing osteoblastic alterations that increase bone brittleness. Although there is growing interest in the management of the physical capability of patients with bone metastasis, the mechanism underlying the impairment of bone mechanical function remains unclear."

Financial support for this research came from JSPS KAKENHI (see also Oncology - Prostate Cancer).

The news reporters obtained a quote from the research from Osaka University, "The alignment of both collagen fibrils and biological apatite (BAp) c-axis, together with bone mineral density, is one of the strongest contributors to bone mechanical function. In this study, we analyzed the bone microstructure of the mouse femurs with and without PCa cell inoculation. Histological assessment revealed that the bone-forming pattern in the PCa-bearing bone was non-directional, resulting in a spongious structure, whereas that in the control bone was unidirectional and layer-by-layer, resulting in a compact lamellar structure. The degree of preferential alignment of collagen fibrils and BAp, which was evaluated by quantitative polarized microscopy and microbeam X-ray diffraction, respectively, were significantly lower in the PCa-bearing bone than in the control bone. Material parameters including Young's modulus and toughness, measured by the three-point bending test, were simultaneously decreased in the PCa-bearing bone. Specifically, there was a significant positive correlation between the degree of BAp c-axis orientation and Young's modulus."

According to the news reporters, the research concluded: "The impairment of mechanical function in the PCa-bearing bone is attributable to disruption of the anisotropic microstructure of bone in multiple phases. This is the first report demonstrating that cancer bone metastasis induces disruption of the collagen/BAp alignment in long bones, thereby impairing their mechanical function."

For more information on this research see: Disruption of collagen/apatite alignment impairs bone mechanical function in osteoblastic metastasis induced by prostate cancer. Bone, 2017;97():83-93. Bone can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier -; Bone -

Our news correspondents report that additional information may be obtained by contacting T. Nakano, Osaka University, Grad Sch Engn, Div Mat & Mfg Sci, Suita, Osaka 5650871, Japan. Additional authors for this research include A. Matsugaki and T. Nakano.

Keywords for this news article include: Osaka, Japan, Asia, Extracellular Matrix Proteins, Connective Tissue Cells, Prostatic Neoplasms, Prostate Cancer, Bone Research, Osteoblasts, Oncology, Collagen, Osaka University.

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