Newswire (Published: Tuesday, May 23, 2017, Received: Thursday, May 18, 2017, 4:01:02 PM CDT)

Word Count: 509

Investigators from Stanford University Have Reported New Data on Prostate Cancer (Genome-wide DNA methylation measurements in prostate tissues uncovers novel prostate cancer diagnostic biomarkers and transcription factor binding patterns)

By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators publish new report on Oncology - Prostate Cancer. According to news originating from Stanford, California, by NewsRx correspondents, research stated, "Current diagnostic tools for prostate cancer lack specificity and sensitivity for detecting very early lesions. DNA methylation is a stable genomic modification that is detectable in peripheral patient fluids such as urine and blood plasma that could serve as a non-invasive diagnostic biomarker for prostate cancer."

Our news journalists obtained a quote from the research from Stanford University, "We measured genome-wide DNA methylation patterns in 73 clinically annotated fresh-frozen prostate cancers and 63 benign-adjacent prostate tissues using the Illumina Infinium HumanMethylation450 BeadChip array. We overlaid the most significantly differentially methylated sites in the genome with transcription factor binding sites measured by the Encyclopedia of DNA Elements consortium. We used logistic regression and receiver operating characteristic curves to assess the performance of candidate diagnostic models. We identified methylation patterns that have a high predictive power for distinguishing malignant prostate tissue from benign-adjacent prostate tissue, and these methylation signatures were validated using data from The Cancer Genome Atlas Project. Furthermore, by overlaying ENCODE transcription factor binding data, we observed an enrichment of enhancer of zeste homolog 2 binding in gene regulatory regions with higher DNA methylation in malignant prostate tissues. DNA methylation patterns are greatly altered in prostate cancer tissue in comparison to benign-adjacent tissue."

According to the news editors, the research concluded: "We have discovered patterns of DNA methylation marks that can distinguish prostate cancers with high specificity and sensitivity in multiple patient tissue cohorts, and we have identified transcription factors binding in these differentially methylated regions that may play important roles in prostate cancer development."

For more information on this research see: Genome-wide DNA methylation measurements in prostate tissues uncovers novel prostate cancer diagnostic biomarkers and transcription factor binding patterns. BMC Cancer, 2017;17():13-22. BMC Cancer can be contacted at: Biomed Central Ltd, 236 Grays Inn Rd, Floor 6, London WC1X 8HL, England. (BioMed Central - www.biomedcentral.com/; BMC Cancer - www.biomedcentral.com/bmccancer/)

The news correspondents report that additional information may be obtained from J.D. Brooks, Stanford University, Medical Center, Dept. of Urol, Stanford, CA 94305, United States. Additional authors for this research include R.C. Ramaker, B.S. Roberts, B.N. Lasseigne, D.S. Gunther, T.C. Burwell, N.S. Davis, Z.G. Gulzar, D.M. Absher, S.J. Cooper, M.K. Kirby and R.M. Myers (see also Oncology - Prostate Cancer).

Keywords for this news article include: Stanford, California, United States, North and Central America, Diagnostics and Screening, Transcription Factors, Carcinoma Diagnostics, Prostatic Neoplasms, Cancer Diagnostics, Prostate Cancer, DNA Research, Proteins, Oncology, Genetics, Stanford University.

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