Newswire (Published: Saturday, September 29, 2018, Received: Thursday, September 20, 2018, 6:37:52 PM CDT)

Word Count: 473

Studies from Boston Children's Hospital in the Area of Prostate Cancer Described (Approaches to the discovery of non-invasive urinary biomarkers of prostate cancer)

By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on Oncology - Prostate Cancer is now available. According to news reporting out of Boston, Massachusetts, by NewsRx editors, research stated, "Prostate cancer (PCa) continues to be one of the most common cancers in men worldwide. Prostate specific antigen (PSA) measured in blood has been used for decades as an aid for physicians to detect the presence of prostate cancer."

Our news journalists obtained a quote from the research from Boston Children's Hospital, "However, the PSA test has limited sensitivity and specificity, leading to unnecessary biopsies, overdiagnosis and overtreatment of patients. For these reasons, there is an urgent need for more accurate PCa biomarkers that can detect PCa with high sensitivity and specificity. Urine is a unique source of potential protein biomarkers that can be measured in a non-invasive way. This review comprehensively summarizes state of the art approaches used in the discovery and validation of urinary biomarkers for PCa. Numerous strategies are currently being used in the discovery of urinary biomarkers for prostate cancer including gel-based separation techniques, mass spectrometry, activity-based proteomic assays and software approaches. Antibody-based approaches remain preferred method for validation of candidate biomarkers with rapidly advancing multiplex immunoassays and MS-based targeted approaches. In the last decade, there has been a dramatic acceleration in the development of new techniques and approaches in the discovery of protein biomarkers for prostate cancer including computational, statistical and data mining methods. Many urinary-based protein biomarkers have been identified and have shown significant promise in initial studies."

According to the news editors, the research concluded: "Examples of these potential biomarkers and the methods utilized in their discovery are also discussed in this review."

For more information on this research see: Approaches to the discovery of non-invasive urinary biomarkers of prostate cancer. Oncotarget, 2018;9(65):32534-32550 (see also Oncology - Prostate Cancer).

Our news journalists report that additional information may be obtained by contacting A. Jedinak, Vascular Biology Program and Dept. of Surgery, Boston Children's Hospital, Boston, MA, United States. Additional authors for this research include K.R. Loughlin and M.A Moses.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.18632/oncotarget.25946. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Boston, Oncology, Biomarkers, Massachusetts, United States, Prostate Cancer, Health and Medicine, Prostatic Neoplasms, North and Central America, Diagnostics and Screening.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2018, NewsRx LLC

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