Newswire (Published: Monday, November 20, 2017, Received: Thursday, November 16, 2017, 2:17:57 PM CST)

Word Count: 434

Studies from Federal University of Minas Gerais Further Understanding of Prostate Cancer (Endothelial Cells as Precursors for Osteoblasts in the Metastatic Prostate Cancer Bone)

By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- New research on Oncology - Prostate Cancer is the subject of a report. According to news reporting out of Belo Horizonte, Brazil, by NewsRx editors, research stated, "Prostate cancer cells metastasize to the bones, causing ectopic bone formation, which results in fractures and pain. The cellular mechanisms underlying new bone production are unknown."

Funders for this research include Pro-reitoria de Pesquisa da Universidade Federal de Minas Gerais (PRPq/UFMG), National Institutes of Health, American Cancer Society Mentored Research Scholar (see also Oncology - Prostate Cancer).

Our news journalists obtained a quote from the research from the Federal University of Minas Gerais, "In a recent study, Lin and colleagues, by using state-of-the-art techniques, including prostate cancer mouse models in combination with sophisticated in vivo lineage-tracing technologies, revealed that endothelial cells form osteoblasts induced by prostate cancer metastasis in the bone. Strikingly, genetic deletion of osteorix protein from endothelial cells affected prostate cancer-induced osteogenesis in vivo."

According to the news editors, the research concluded: "Deciphering the osteoblasts origin in the bone microenvironment may result in the development of promising new molecular targets for prostate cancer therapy."

For more information on this research see: Endothelial Cells as Precursors for Osteoblasts in the Metastatic Prostate Cancer Bone. Neoplasia, 2017;19(11):928-931. Neoplasia can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA.

Our news journalists report that additional information may be obtained by contacting A. Birbrair, Federal University of Minas Gerais, Dept. of Pathol, Belo Horizonte, MG, Brazil. Additional authors for this research include L. Lousado, V.M. Almeida, J.P. Andreotti, G.S.P. Santos, P.O. Azevedo, I.F.G. Sena, P. Prazeres, I.T. Borges, V. Azevedo, A. Mintz and A.E. Paiva.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.neo.2017.08.007. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Belo Horizonte, Brazil, South America, Metastatic Prostate Cancer, Connective Tissue Cells, Drugs and Therapies, Cancer Gene Therapy, Prostatic Neoplasms, Endothelial Cells, Bone Research, Biotechnology, Osteoblasts, Oncology, Federal University of Minas Gerais.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

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Subjects

Science and Technology
      Scientific Research
Health and Wellness
      Medical Conditions and Diseases
            Cancer
                  Prostate Cancer
            Men's Health Issues
                  Prostate Cancer
      Treatments and Therapies