Newswire (Published: Tuesday, January 24, 2017, Received: Thursday, January 19, 2017, 11:27:10 PM CST)

Word Count: 490

Studies Conducted at University of Oslo on Prostate Cancer Recently Reported (Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers)

By a News Reporter-Staff News Editor at Cancer Weekly -- Researchers detail new data in Oncology - Prostate Cancer. According to news reporting originating from Oslo, Norway, by NewsRx correspondents, research stated, "Exosomes have recently appeared as a novel source of noninvasive cancer biomarkers, since these nanovesicles contain molecules from cancer cells and can be detected in biofluids. We have here investigated the potential use of lipids in urinary exosomes as prostate cancer biomarkers."

Our news editors obtained a quote from the research from the University of Oslo, "A high-throughput mass spectrometry quantitative lipidomic analysis was performed to reveal the lipid composition of urinary exosomes in prostate cancer patients and healthy controls. Control samples were first analysed to characterise the lipidome of urinary exosomes and test the reproducibility of the method. In total, 107 lipid species were quantified in urinary exosomes. Several differences, for example, in cholesterol and phosphatidylcholine, were found between urinary exosomes and exosomes derived from cell lines, thus showing the importance of in vivo studies for biomarker analysis. The 36 most abundant lipid species in urinary exosomes were then quantified in 15 prostate cancer patients and 13 healthy controls. Interestingly, the levels of nine lipids species were found to be significantly different when the two groups were compared. The highest significance was shown for phosphatidylserine (PS) 18:1/18:1 and lactosylceramide (d18:1/16:0), the latter also showed the highest patient-to-control ratio. Furthermore, combinations of these lipid species and PS 18:0-18:2 distinguished the two groups with 93% sensitivity and 100% specificity. Finally, in agreement with the reported dysregulation of sphingolipid metabolism in cancer cells, alteration in specific sphingolipid lipid classes were observed."

According to the news editors, the research concluded: "This study shows for the first time the potential use of exosomal lipid species in urine as prostate cancer biomarkers."

For more information on this research see: Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers. European Journal of Cancer, 2017;70():122-132. European Journal of Cancer can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; European Journal of Cancer - www.journals.elsevier.com/european-journal-of-cancer/)

The news editors report that additional information may be obtained by contacting A. Llorente, University of Oslo, Center Canc Biomed, Fac Med, N-0379 Oslo, Norway. Additional authors for this research include K. Ekroos, D. Kauhanen, H. Simolin, T. Seierstad, V. Berge, K. Sandvig and A. Llorente (see also Oncology - Prostate Cancer).

Keywords for this news article include: Oslo, Norway, Europe, Cancer, Diagnostics and Screening, Cytoplasmic Structures, Prostatic Neoplasms, Transport Vesicles, Prostate Cancer, Organelles, Oncology, Exosomes, University of Oslo.

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