Newswire (Published: Tuesday, February 21, 2017, Received: Thursday, February 16, 2017, 10:20:57 PM CST)

Word Count: 386

Researchers from Cleveland Clinic Describe Findings in Prostate Cancer (Clinical and molecular rationale to retain the cancer descriptor for Gleason score 6 disease)

By a News Reporter-Staff News Editor at Cancer Weekly -- New research on Oncology - Prostate Cancer is the subject of a report. According to news reporting out of Cleveland, Ohio, by NewsRx editors, research stated, "Treatment choices for men with indolent prostate cancer include active surveillance or definitive local therapy. Overtreatment of these patients is an important current problem."

Our news journalists obtained a quote from the research from Cleveland Clinic, "Treatment decisions are often made jointly by the clinician and the patient, partly based on the tumour's Gleason score. To reduce the burden of overtreatment, the clinical significance of Gleason score 3 + 3 = 6 prostate cancer has been questioned and some have advocated that Gleason pattern 3 should be stripped of its cancer status. However, removing the cancer descriptor would have far-reaching clinical consequences that might result in poor patient outcomes, as the evidence of a lack of malignancy is inconclusive in several areas. For example, molecular data suggest that the genomic instability underlying tumour progression precedes histologically visible changes and the absolute risk of metastasis or mortality from Gleason score 6 prostate cancer is not zero."

According to the news editors, the research concluded: "Extreme caution is required when weighing a decision to reclassify Gleason pattern 3 disease as a non-cancer."

For more information on this research see: Clinical and molecular rationale to retain the cancer descriptor for Gleason score 6 disease. Nature Reviews Urology, 2017;14(1):59-64. Nature Reviews Urology can be contacted at: Nature Publishing Group, 75 Varick St, 9TH Flr, New York, NY 10013-1917, USA. (Nature Publishing Group -; Nature Reviews Urology -

Our news journalists report that additional information may be obtained by contacting E.A. Klein, Cleveland Clinic, Glickman Urol & Kidney Inst, Cleveland, OH 44195, United States (see also Oncology - Prostate Cancer).

Keywords for this news article include: Cleveland, Ohio, United States, North and Central America, Cancer, Risk and Prevention, Epidemiology, Prostatic Neoplasms, Prostate Cancer, Oncology, Genetics, Cleveland Clinic.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC


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