Newswire (Published: Tuesday, January 31, 2017, Received: Thursday, January 26, 2017, 9:05:41 PM CST)

Word Count: 606

Findings on Prostate Cancer Reported by Investigators at National Cancer Institute (Trends in the Incidence of Fatal Prostate Cancer in the United States by Race)

By a News Reporter-Staff News Editor at Cancer Weekly -- New research on Oncology - Prostate Cancer is the subject of a report. According to news reporting from Bethesda, Maryland, by NewsRx journalists, research stated, "Prostate-specific antigen (PSA) testing has dramatically changed the composition of prostate cancer (PCa), making it difficult to interpret incidence trends. New methods are needed to examine temporal trends in the incidence of clinically significant PCa and whether trends vary by race."

The news correspondents obtained a quote from the research from National Cancer Institute, "To conduct an in-depth analysis of incidence trends in clinically significant PCa, defined as cases in which PCa was the underlying cause of death within 10 yr of diagnosis. setting, and participants: We extracted incident PCa cases during the period 1975-2002 and associated causes of death and survival through 2012 from nine cancer registries in the population-based Surveillance Epidemiology and End Results program database. Outcome measurements and statistical analysis: We applied joinpoint regression analysis to identify when significant changes in trends occurred and age-period-cohort models to examine longitudinal and cross-sectional trends in the incidence of fatal PCa. Results and limitations: Among 51 680 fatal PCa cases, incidence increased 1% per year prior to 1992, declined 15% per year from 1992 to 1995, and further declined by 5% per year through 2002. Age-specific incidence rates of fatal disease decreased >2% per year among men aged >= 60 yr, yet rates remained relatively stable among men aged <= 55 yr. Fatal disease rates were >2-fold higher in black men compared with white men, a racial disparity that increased to 4.2-fold among younger men. The incidence of fatal PCa substantially declined after widespread PSA screening and treatment advances. Nevertheless, rates of fatal disease among younger men have remained relatively stable, suggesting the need for additional attention to early onset PCa, especially among black men. The persistent black-to-white racial disparity observed in fatal PCa underscores the need for greater understanding of the causes of this difference so that strategies can be implemented to eliminate racial disparities. Patient summary: We assessed how the incidence of ultimately fatal prostate cancer (PCa) changed over time."

According to the news reporters, the research concluded: "We found that the incidence of fatal PCa declined by > 50% since the introduction of prostate-specific antigen testing and advances in treatment options; however, incidence rates among younger men remained relatively stable, and younger black men exhibited a 4.2-fold higher risk for fatal disease compared with white men. ."

For more information on this research see: Trends in the Incidence of Fatal Prostate Cancer in the United States by Race. European Urology, 2017;71(2):195-201. European Urology can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier -; European Urology -

Our news journalists report that additional information may be obtained by contacting M.B. Cook, National Cancer Institute, Div Canc Epidemiol & Genet, National Institutes of Health, Bethesda, MD 20892, United States. Additional authors for this research include P.S. Rosenberg, W.F. Anderson, G. Andreotti, N. Younes, S.D. Cleary and M.B. Cook (see also Oncology - Prostate Cancer).

Keywords for this news article include: Bethesda, Maryland, United States, North and Central America, Cancer, Diagnostics and Screening, Epidemiology, Prostatic Neoplasms, Prostate Cancer, Oncology, National Cancer Institute.

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