Newswire (Published: Tuesday, February 7, 2017, Received: Thursday, February 2, 2017, 7:03:14 PM CST)

Word Count: 395

Investigators at University of Michigan Zero in on Prostate Cancer (The marrow niche controls the cancer stem cell phenotype of disseminated prostate cancer)

By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Oncology - Prostate Cancer have been published. According to news reporting originating in Ann Arbor, Michigan, by NewsRx journalists, research stated, "Dissemination of cancer stem cells (CSCs) serves as the basis of metastasis. Recently, we demonstrated that circulating prostate cancer targets the hematopoietic stem cell (HSCs) 'niche' in marrow during dissemination."

The news reporters obtained a quote from the research from the University of Michigan, "Once in the niche, disseminated tumor cells (DTCs) may remain dormant for extended periods. As the major function of the HSC niche is to maintain stem cell functions, we hypothesized that the niche regulates CSC activities of DTCs. Here we show that DTCs recovered from marrow were significantly enriched for a CSC phenotype. Critically, the conversion of DTCs to CSCs is regulated by niche-derived GAS6 through the Mer/mTOR; molecules previously shown to regulate dormancy. The data demonstrate that the niche plays a significant role in maintaining tumor-initiating prostate cancer in marrow and suggests a functional relationship between CSCs and dormancy."

According to the news reporters, the research concluded: "Understanding how the marrow niche regulates the conversion of DTCs to CSCs is critical for the development of therapeutics specifically targeting skeletal bone metastasis and dormancy."

For more information on this research see: The marrow niche controls the cancer stem cell phenotype of disseminated prostate cancer. Oncotarget, 2016;7(27):41217-41232 (see also Oncology - Prostate Cancer).

Our news correspondents report that additional information may be obtained by contacting Y. Shiozawa, Dept. of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109, United States. Additional authors for this research include J.E. Berry, M.R. Eber, Y. Jung, K. Yumoto, F.C. Cackowski, H.J. Yoon, P. Parsana, R. Mehra, J. Wang, S. McGee, E. Lee, S. Nagrath, K.J. Pienta and R.S Taichman.

Keywords for this news article include: Michigan, Oncology, Ann Arbor, United States, Prostate Cancer, Stem Cell Research, Prostatic Neoplasms, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

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