Newswire (Published: Tuesday, October 3, 2017, Received: Friday, September 29, 2017, 12:46:19 AM CDT)

Word Count: 493

Reports from Lenox Hill Hospital Advance Knowledge in Prostate Cancer (Heterogeneity of Outcomes in D'Amico Intermediate-Risk Prostate Cancer Patients after Radical Prostatectomy: Influence of Primary and Secondary Gleason Score)

By a News Reporter-Staff News Editor at Cancer Weekly -- Fresh data on Oncology - Prostate Cancer are presented in a new report. According to news reporting originating in New York City, New York, by NewsRx journalists, research stated, "The aim of this study was to clarify and examine the outcomes of prostate cancer patients classified as intermediate risk (IR) using the D'Amico risk classification system, specifically focusing on the influence of primary and secondary biopsy Gleason score (BGS). An institutional review board-approved database of robotic-assisted radical prostatectomies performed after 2006 was stratified by standard D'Amico criteria."

The news reporters obtained a quote from the research from Lenox Hill Hospital, "IR patients were then sub-stratified by BGS. Pathologic and intermediate-term biochemical disease-free survival (BDFS) outcomes were analyzed. Overall, 1,090 patients were classified as D'Amico low-risk, 896 as IR, and 240 as high-risk. Of the 896 IR patients, 63 had BGS 6, 630 were 3 + 4 = 7, and 203 4 + 3 = 7. Among IR patients, as the BGS increased, there was an increasing likelihood of extracapsular extension (21, 28, and 38%, respectively; p = 0.005), positive surgical margins (14, 26, 31%; p = 0.048), and worse 3-year BDFS (96, 94, 88%; p = 0.01). Multivariable logistic regression and Cox regression analyses confirmed differences among IR groups. D'Amico IR patients demonstrate significant heterogeneity in both pathologic outcomes and BDFS. IR patients with a BGS of 6 appear to have similar intermediate-term BDFS as low-risk patients."

According to the news reporters, the research concluded: "An increasing BGS from 3 + 3 to 3 + 4 to 4 + 3 results in a higher likelihood of locally-advanced disease and intermediate-term biochemical failure."

For more information on this research see: Heterogeneity of Outcomes in D'Amico Intermediate-Risk Prostate Cancer Patients after Radical Prostatectomy: Influence of Primary and Secondary Gleason Score. Oncology Research and Treatment, 2017;40(9):508-514. Oncology Research and Treatment can be contacted at: Karger, Allschwilerstrasse 10, Ch-4009 Basel, Switzerland (see also Oncology - Prostate Cancer).

Our news correspondents report that additional information may be obtained by contacting D.B. Samadi, Lenox Hill Hosp, Hofstra Northwell Sch Med, Dept. of Urol, New York, NY 10021, United States. Additional authors for this research include A.R. Hobbs, Y.S. Kwon, M. Katsigeorgis, H.J. Lavery, A. Levinson, A.N. Bernstein, S.A. Collingwood, S.J. Hall, M.E. Pollard and S.B. Jazayeri.

Keywords for this news article include: New York City, New York, United States, North and Central America, Male Urologic Surgical Procedures, Prostatic Neoplasms, Prostate Cancer, Prostatectomy, Biochemicals, Biochemistry, Men's Health, Chemicals, Oncology, Surgery, Lenox Hill Hospital.

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