Newswire (Published: Tuesday, October 3, 2017, Received: Friday, September 29, 2017, 12:17:13 AM CDT)

Word Count: 393

Findings on Prostate Cancer Detailed by Researchers at University of Alberta (Gene-Set Reduction for Analysis of Major and Minor Gleason Scores Based on Differential Gene-Set Expressions and Biological Pathways in Prostate Cancer)

By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators publish new report on Oncology - Prostate Cancer. According to news originating from Edmonton, Canada, by NewsRx correspondents, research stated, "The Gleason score (GS) plays an important role in prostate cancer detection and treatment. It is calculated based on a sum between its major and minor components, each ranging from 1 to 5, assigned after examination of sample cells taken from each side of the prostate gland during biopsy."

Our news journalists obtained a quote from the research from the University of Alberta, "A total GS of at least 7 is associated with more aggressive prostate cancer. However, it is still unclear how prostate cancer outcomes differ for various distributions of GS between its major and minor components. This article applies Significance Analysis of Microarray for Gene-Set Reduction to a real microarray study of patients with prostate cancer and identifies 13 core genes differentially expressed between patients with a major GS of 3 and a minor GS of 4, or (3,4), vs patients with a combination of (4,3), starting from a less aggressive GS combination of (3,3), and moving toward a more aggressive one of (4,4) via gray areas of (3,4) and (4,3)."

According to the news editors, the research concluded: "The resulting core genes may improve understanding of prostate cancer in patients with a total GS of 7, the most common grade and most challenging with respect to prognosis."

For more information on this research see: Gene-Set Reduction for Analysis of Major and Minor Gleason Scores Based on Differential Gene-Set Expressions and Biological Pathways in Prostate Cancer. Cancer Informatics, 2017;16():1176935117730016 (see also Oncology - Prostate Cancer).

The news correspondents report that additional information may be obtained from I. Dinu, School of Public Health, University of Alberta, Edmonton, AB, Canada. Additional authors for this research include S. Poudel and S. Pyne.

Keywords for this news article include: Canada, Alberta, Edmonton, Genetics, Oncology, Prostate Cancer, Prostatic Neoplasms, North and Central America.

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