Newswire (Published: Tuesday, March 14, 2017, 12:01:00 AM CDT, Received: Thursday, March 9, 2017, 9:51:32 PM CST)

Word Count: 458

New Data from National Institute of Health Sciences Illuminate Findings in Prostate Cancer (Celastrol, an active constituent of the TCM plant Tripterygium wilfordii Hook.f., inhibits prostate cancer bone metastasis)

By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Oncology - Prostate Cancer have been published. According to news reporting out of Tokyo, Japan, by NewsRx editors, research stated, "Treatment failure of prostate cancer (PCa) is often due to bone metastasis. Celastrol, an active constituent of Tripterygium wilfordii roots, has shown anti-tumor effects in previous studies in accordance with its indication in traditional Chinese medicine."

Our news journalists obtained a quote from the research from the National Institute of Health Sciences, "Using a PC-3 cell model, in vitro assays were performed to evaluate the effects of celastrol on proliferation, migration (wound healing assay), tissues invasion (Transwell-Matrigel penetration assay) and vascular endothelial growth factor (VEGF) secretion (enzyme-linked immunosorbent assay). An intra-tibia injection mouse model was used to assess the effect of celastrol on PCa bone metastasis in vivo. Pretreatment with celastrol significantly reduced proliferation of PC-3 cells in a dose-dependent manner and cell migration was much slower than in controls. Significantly fewer cells penetrated the gel-membrane after celastrol administration and their skeletal invasive ability was significantly reduced in a dose-dependent manner. Correspondingly, a significant, dose-dependent decrease in VEGF secretion was observed. In the in vivo mouse model, pretreatment with celastrol (8 mmol l) inhibited the tumorigenicity of PC-3 cells so that almost no bone invasion occurred as compared with control injections. Histological examinations using hematoxylin and eosin staining showed that tibiae injected with celastrol pretreated PC-3 cells retained their natural bone structure."

According to the news editors, the research concluded: "Celastrol may have preventive potential against PCa bone metastasis.Prostate Cancer and Prostatic Diseases advance online publication, 14 February."

For more information on this research see: Celastrol, an active constituent of the TCM plant Tripterygium wilfordii Hook.f., inhibits prostate cancer bone metastasis. Prostate Cancer and Prostatic Diseases, 2017;():. (Nature Publishing Group -; Prostate Cancer and Prostatic Diseases -

Our news journalists report that additional information may be obtained by contacting K. Kuchta, Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan. Additional authors for this research include Y. Xiang, S. Huang, Y. Tang, X. Peng, X. Wang, Y. Zhu, J. Li, J. Xu, Z. Lin and T. Pan (see also Oncology - Prostate Cancer).

Keywords for this news article include: Asia, Tokyo, Japan, Oncology, Bone Research, Prostate Cancer, Prostatic Neoplasms.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC


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