Newswire (Published: Tuesday, June 6, 2017, Received: Thursday, June 1, 2017, 7:10:54 PM CDT)

Word Count: 399

By a News Reporter-Staff News Editor at Cancer Weekly -- Fresh data on Oncology - Prostate Cancer are presented in a new report. According to news originating from New York City, New York, by NewsRx correspondents, research stated, "This article intends to review biomarkers derived from blood, urine, and tissue that can aid in the diagnosis of prostate cancer (PCa). PCa screening requires tools that complement prostate-specific antigen (PSA) with a higher specificity for clinically significant disease."

Our news journalists obtained a quote from the research, "Novel blood biomarkers, such as the Prostate Health Index (phi) and 4Kscore, utilize isoforms of PSA to more accurately predict high-grade PCa than traditional tools such as PSA and the percentage free-to-total PSA. Several gene products associated with PCa can be detected in the urine through commercially available assays. PCa antigen 3 (PCA3), though approved for repeat biopsy decisions, appears inferior to other biomarkers such as phi for identifying aggressive disease. However, combinations of PCA3 with other urine assays have shown promising results. One tissue-based hypermethylation test, named ConfirmMDx, can also be used to determine the need for repeat biopsy in men with a prior negative biopsy. Several biomarkers have been developed to aid in the screening and diagnosis of PCa. Such tests are often indicated in men with moderately elevated PSA or history of a prior negative biopsy."

According to the news editors, the research concluded: "Their use facilitates reduction of unnecessary biopsies without sacrificing the early diagnosis of clinically significant PCa."

For more information on this research see: The role of prostate cancer biomarkers in undiagnosed men. Current Opinion in Urology, 2017;27(3):210-216. Current Opinion in Urology can be contacted at: Lippincott Williams & Wilkins, Two Commerce Sq, 2001 Market St, Philadelphia, PA 19103, USA. (Lippincott Williams and Wilkins - www.lww.com; Current Opinion in Urology - journals.lww.com/co-urology/pages/default.aspx)

The news correspondents report that additional information may be obtained from S. Loeb, Manhattan Vet Affairs Med Center, New York, NY, United States (see also Oncology - Prostate Cancer).

Keywords for this news article include: New York City, New York, United States, North and Central America, Cancer, Article Review, Diagnostics and Screening, Prostate-Specific Antigen, Enzymes and Coenzymes, Prostatic Neoplasms, Prostate Cancer, Oncology.

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