Newswire (Published: Tuesday, September 25, 2018, Received: Friday, September 21, 2018, 2:41:00 AM CDT)

Word Count: 516

By a News Reporter-Staff News Editor at Cancer Weekly -- A new study on Oncology - Prostate Cancer is now available. According to news reporting from Baltimore, Maryland, by NewsRx journalists, research stated, "The human microbiome may influence prostate cancer initiation and/or progression through both direct and indirect interactions. To date, the majority of studies have focused on direct interactions including the influence of prostate infections on prostate cancer risk and, more recently, on the composition of the urinary microbiome in relation to prostate cancer."

The news correspondents obtained a quote from the research from Johns Hopkins University, "Less well understood are indirect interactions of the microbiome with prostate cancer, such as the influence of the gastrointestinal or oral microbiota on pro- or anti-carcinogenic xenobiotic metabolism, and treatment response. We review the literature to date on direct and indirect interactions of the microbiome with prostate inflammation and prostate cancer. Emerging studies indicate that the microbiome can influence prostate inflammation in relation to benign prostate conditions such as prostatitis/chronic pelvic pain syndrome and benign prostatic hyperplasia, as well as in prostate cancer. We provide evidence that the human microbiome present at multiple anatomic sites (urinary tract, gastrointestinal tract, oral cavity, etc.) may play an important role in prostate health and disease. In health, the microbiome encourages homeostasis and helps educate the immune system. In dysbiosis, a systemic inflammatory state may be induced, predisposing remote anatomical sites to disease, including cancer. The microbiome's ability to affect systemic hormone levels may also be important, particularly in a disease such as prostate cancer that is dually affected by estrogen and androgen levels."

According to the news reporters, the research concluded: "Due to the complexity of the potential interconnectedness between prostate cancer and the microbiome, it is vital to further explore and understand the relationships that are involved."

For more information on this research see: The microbiome in prostate inflammation and prostate cancer. Prostate Cancer and Prostatic Diseases, 2018;21(3):345-354. Prostate Cancer and Prostatic Diseases can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - www.nature.com/; Prostate Cancer and Prostatic Diseases - www.nature.com/pcan/)

Our news journalists report that additional information may be obtained by contacting K.S. Sfanos, Johns Hopkins University, Sch Med, Dept. of Urol, James Buchanan Brady Urol Inst, Baltimore, MD 21205, United States. Additional authors for this research include E. Shrestha, L.B. Peiffer and C.M. Porter (see also Oncology - Prostate Cancer).

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1038/s41391-018-0041-1. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Baltimore, Maryland, United States, North and Central America, Health and Medicine, Risk and Prevention, Prostatic Neoplasms, Prostate Cancer, Inflammation, Oncology, Johns Hopkins University.

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