Newswire (Published: Tuesday, February 28, 2017, Received: Friday, February 24, 2017, 9:41:13 AM CST)

Word Count: 431

Researchers at University of California - San Francisco Report Findings in Prostate Cancer (Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer)

By a News Reporter-Staff News Editor at Cancer Weekly -- New research on Oncology - Prostate Cancer is the subject of a report. According to news reporting originating in San Francisco, California, by NewsRx journalists, research stated, "Prostate-specific antigen (PSA) levels have been used for detection and surveillance of prostate cancer (PCa). However, factors other than PCa-such as genetics-can impact PSA."

The news reporters obtained a quote from the research from the University of California - San Francisco, "Here we present findings from a genome-wide association study (GWAS) of PSA in 28,503 Kaiser Permanente whites and 17,428 men from replication cohorts. We detect 40 genome-wide significant (p <5 ? 10) single-nucleotide polymorphisms (SNPs): 19 novel, 15 previously identified for PSA (14 of which were also PCa-associated), and 6 previously identified for PCa only. Further analysis incorporating PCa cases suggests that at least half of the 40 SNPs are PSA-associated independent of PCa. The 40 SNPs explain 9.5% of PSA variation in non-Hispanic whites, and the remaining GWAS SNPs explain an additional 31.7%; this percentage is higher in younger men, supporting the genetic basis of PSA levels."

According to the news reporters, the research concluded: "These findings provide important information about genetic markers for PSA that may improve PCa screening, thereby reducing over-diagnosis and over-treatment."

For more information on this research see: Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer. Nature Communications, 2017;8():14248. (Nature Publishing Group - www.nature.com/; Nature Communications - www.nature.com/ncomms/)

Our news correspondents report that additional information may be obtained by contacting T.J. Hoffmann, Dept. of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94158, United States. Additional authors for this research include M.N. Passarelli, R.E. Graff, N.C. Emami, L.C. Sakoda, E. Jorgenson, L.A. Habel, J. Shan, D.K. Ranatunga, C.P. Quesenberry, C.R. Chao, N.R. Ghai, D. Aaronson, J. Presti, T. Nordstrom, Z. Wang, S.I. Berndt and S. Chanock (see also Oncology - Prostate Cancer).

Keywords for this news article include: Genetics, Oncology, California, Kallikreins, Epidemiology, San Francisco, United States, Endopeptidases, Prostate Cancer, Serine Proteases, Peptide Hydrolases, Prostatic Neoplasms, Enzymes and Coenzymes, North and Central America, Prostate Specific Antigen.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

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