Newswire (Published: Tuesday, March 14, 2017, 12:01:00 AM CDT, Received: Thursday, March 9, 2017, 4:15:07 PM CST)

Word Count: 494

Research Conducted at University of Pittsburgh Has Provided New Information about Prostate Cancer (Human herpesvirus 8 infection contributes to a T helper 2 immune response in men from Tobago with prostate cancer)

By a News Reporter-Staff News Editor at Virus Weekly -- Research findings on Oncology - Prostate Cancer are discussed in a new report. According to news reporting originating in Pittsburgh, Pennsylvania, by NewsRx journalists, research stated, "To compare the cytokine profile between human herpesvirus 8 seropositive and seronegative men with and without prostate cancer. The study sample was obtained from the Tobago Prostate Survey, an ongoing study of prostate cancer in the Caribbean island of Tobago."

Funders for this research include U.S. Department of Defense, National Institutes of Health, University of Pittsburgh (see also Oncology - Prostate Cancer).

The news reporters obtained a quote from the research from the University of Pittsburgh, "Participants in the study were recruited mostly by public service announcement and by word of mouth. For analyses of circulating levels of pro-inflammatory cytokines, participants with biopsy-confirmed prostate cancer (n = 79) were compared with control participants (n = 87). Cytokine analyses showed a T helper 2 response with suppressed T helper 1 response in prostate cancer patients, as evidenced by significantly increased levels of interleukin-13 and reduced levels of interleukin-12p70. Herpesvirus 8 seropositive men showed significantly increased levels of interleukin-13 and interleukin-10. At logistic regression analyses, interleukin-12p70 predicted prostate cancer in 94.4% of human herpesvirus 8 seropositive men. These findings show that prostate cancer elicits an antitumor, T helper 2 response with a suppressed T helper 1 response."

According to the news reporters, the research concluded: "Human herpesvirus 8 infection results in a similar immune response supporting the hypothesis that in Tobago, human herpesvirus 8 establishes a chronic infection that can contribute to an immune response favoring the formation and survival of prostate cancer."

For more information on this research see: Human herpesvirus 8 infection contributes to a T helper 2 immune response in men from Tobago with prostate cancer. International Journal of Urology, 2017;24(1):64-68. International Journal of Urology can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; International Journal of Urology - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1442-2042)

Our news correspondents report that additional information may be obtained by contacting F.J. Jenkins, University of Pittsburgh, Dept. of Pathol, Pittsburgh, PA, United States. Additional authors for this research include L.A. Bonachea, C.H. Bunker, A.L. Patrick and F.J. Jenkins.

Keywords for this news article include: Pittsburgh, Pennsylvania, United States, North and Central America, Intercellular Signaling Peptides and Proteins, Human Herpesvirus Diseases and Conditions, Human Herpesvirus 8, Prostatic Neoplasms, Vertebrate Viruses, Oncogenic Viruses, DNA Tumor Viruses, Prostate Cancer, Interleukins, Rhadinovirus, Cytokines, Virology, Oncology, Viral, HHV-8, HHV8, University of Pittsburgh.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

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